Necroptosis: Molecular Signalling and Translational Implications

Necroptosis: Molecular Signalling and Translational Implications

Blog Article

Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death.Here BOXERS we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP Japanese BBQ proteins in the apoptosis/necroptosis balance.We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.